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Vacuum freeze dryer

Pharmaceutical freeze drying machine, also can be called pharmaceutical lyophilizer with overlay refrigeration technology which can shorten freeze-drying time. And can be linked with the vial freeze drying powder production line to form a fully automatic one stop solution.

Core Advantages
Core Technology
Technical Parameters
Application Scenarios
Optional Systems

1. Introduction

The working principle of the vacuum freeze-dryer is to make the water in the pre-frozen drug to in the vacuum state, based on use the sublimation principle, not through the ablation of ice, directly sublimate into water vapor and to be removed, so as to achieve the purpose of drug freeze-drying. The pharmaceutical freeze dryer combines refrigeration system, vacuum system, heat conduction oil heating system and dehumidification system. The freeze dry supplier introduces a new type of box structure, which can be divided into laboratory freeze drying machine, raw material freeze drying machine, pilot production freeze drying machine, industrial freeze drying machine and so on. The freeze-drying products are spongy, dry-shrinking, excellent rehydration, little moisture content, and can be stored and transported at room temperature for a long time after packaging; Widely used in raw materials, Chinese medicine pieces, biological products, vaccines, blood products, active substances, antibiotics, food, fruit, chemical, pharmaceutical intermediates and other materials drying production.

2. Performance characteristics
- The whole vacuum freeze drying machine design, material, manufacture, assembly, commissioning and so on are in line with the new GMP and FDA drug production specifications;
- Applicable vial bottle specification: 1ml-100ml;
- Capacity up to 300-182000 bottles / case (according to the size of the bottle);
- Imported refrigeration compressor, reliable work, long service life;
- Overlay refrigeration technology, shorten freeze-drying time, import brand guarantee, reduce noise, large refrigerating capacity, large water capture capacity, high quality guarantee high performance;
- Equipped with observation window, freeze drying process intuitive. In-situ pre-freezing is used to realize the automation from vacuum to drying and reduce the tedious operation of drying process;
- The freeze-drying room is made of stainless steel, easy to clean and durable;
- Silicone oil freezing medium, error ≤1℃, drying effect is uniform;
- Equipped with inflatable valve, can be filled with dry inert gas;
- High quality square shelf is not easy to deform, easy to operate, easy to clean;
- diaphragm flatness less than 1 mm, temperature difference less than 1 degree;
- Equipment refrigeration quality in line with environmental requirements;
- Vacuum connection adopts international standard parts, easy to disassemble and install, reliable sealing performance;
- Optional temperature recorder. Adjustable temperature recording points, real-time monitoring, for your experience to increase the protection;
- Can be equipped with energy-saving control function;
- Optional eutectic point test device;
- Optional automatic negative pressure plug device (cover type freeze-drying machine);
- Optional on-line cleaning CIP、 sterilization SIP;
- Can combine with vial bottle production line, automatic feeding and feeding system to form a whole freeze-drying preparation automatic production solution;
- Touch screen LCD display, curve and data display drying process, new PID control, convenient for users to know more information according to data changes;
- According to the actual needs of customers to customize the product freeze-drying process curve;
- Layout can be customized according to customer layout requirements to achieve the overall or split design, saving installation space.

Why MARYA

Trusted Worldwide

20 +

Years rich Industry Experience

3 +

Production Bases

60 +

Successful Projects in 60 Countries

300 +

Loyal Clientele

Company Honors and Certificates

CE Bottle unscrambler and labeling machine

Some of Our Customers

Well - known visiting Clients

Invited to the Embassy of the United Republic of Tanzania in Guangzhou to discuss projects

Tanzanian Vice President Visits Marya Pharmaceutical EPC Project

NBA (Zimbabwe National Biotechnology Authority) conducts FAT at MARYA’s Factory

NOVO NORDISK client Visit

Clients visit the factory's liquid preparation system

Argentine client visits for FAT in MARYA

Successful Cases

Zimbabwe Vial Filling Line

Malaysia Prefilled Syringe Filling line

Argentina Vial and Ampoule line

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Services

Full-process Consulting Services

Whether you are preparing to build a new pharmaceutical factory, build a cleanroom that complies with local GMP regulations, or purchase pharmaceutical equipment to develop a new production line, whether it is a separate cleanroom or pharmaceutical machine project, or a one-stop solution, Marya's professional teams in the fields of pharmaceutical technical process, process equipment, decoration engineering, HVAC engineering, pipeline engineering, utility equipment, intelligent automatic control systems, project cost and other fields can provide you with full-process technical consulting services, and solve your needs one-on-one.

2D/3D Design Modeling Services

Marya project design team is composed of professional CAD and BIM engineers with more than 20 years of comprehensive industry experience and can provide you with comprehensive design services, including but not limited to process layout drawings, technical process charts, 3D models and animations, air conditioning system scheme design, construction drawing design, plant/pharmaceutical machine layout drawings, etc.

Machine Customization Services

Based on the individual needs of clients in different countries, Marya helps you clarify specific needs, match appropriate models, and customize one stop filling solutions for sterile small-volume preparations, large-volume injections, oral liquids/syrups, solid preparations, etc.

Validation Services (FAT/SAT)

Marya will appoint an engineer with rich project management experience as the person in charge, who will be fully responsible for project management and liaison work. After the equipment is manufactured, our engineers and the buyer's representatives will participate in the FAT test. After the equipment arrives at the buyer's site, it will be installed and debugged. After the equipment reaches optimal operation, the buyer will conduct SAT testing and inspection.

Customer FAQ

Are you manufacturer or trader? Where are your factory located?

We are manufacturer. Our factory is located in Changsha and Suzhou.

What certificate do you have?

We have CE, ISO, ROHS, SGS etc.

What documents will you provide?

Usually we will provide DQ, IQ, PQ, OQ, FAT, SAT, operation manual, maintenance instruction,layout drawing.etc.

What is the production lead time?

Standard 25-60 days after deposit received and technical data confirmed, we can make special arrangement for better shipment if needed;
Standard 60-150 days after deposit received and technical data confirmed based on different machines, we can make special arrangement for better shipment if needed.

How long is your warranty? Can we extend?

12 months after installation and commissioning or 18 moths from the day that the equipment arrived on site. Prevail in the first arrival date.
Warranty can be extended with extra charge.

Have you done similar projects overseas?

Marya’s business map covers more than 60 countries and regions around the world, such as the United States, Russia, Bulgaria, Britain, Portugal, Poland, Switzerland, ltaly, New Zealand, Malta, Moldova, Malaysia, Uzbekistan, lran, Egypt, Saudi Arabia, UAE, Ecuador, Dominica, Panama, Uruguay, Argentina, Tanzania, Zimbabwe, Ethiopia, Indonesia, Bangladesh, and others, and we gained good reputation.

Key words:

Vacuum freeze dryer

freeze dryer machine

freeze drying machine

freeze drying process

lyophilizer

Automatic rubber plug (aluminum cover) cleaning machine

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