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Products

Cartridge Filling Machine

The Marya Cartridge Filling Line is a highly efficient and accurate automated filling equipment designed for cartridge bottles, which is widely used in pharmaceutical, cosmetic, food, and other industries. The production line integrates advanced filling technology to ensure high product quality and consistency while increasing production efficiency and reducing labor costs. The entire line meets the new GMP requirements.

Core Advantages
Core Technology
Technical Parameters
Application Scenarios
Optional Systems

High-precision filling: Adopting advanced metering system to ensure filling accuracy within ±0.5% deviation;
Aseptic guarantee: Equipped with Open-RABS or isolator system;
Efficient production: Fully automated with high-speed filling, reaching up to 400 bottles per minute, significantly improving efficiency;
High flexibility: Adaptable to different sizes of cartridge bottle specifications with quick changeover, reducing downtime;
High regulatory compliance: Made of 316L stainless steel, conforming to GMP standards, easy to clean and maintain, ensuring product hygiene and safety;
High stability: Equipped with advanced sensor and control system to ensure stable equipment operation and reduce failure rate;
Intelligent control:
· Adopting high precision color touch screen operation and monitoring, PLC automatic control, automatic protection, host frequency conversion speed regulation and other control technologies for fully automatic control and monitoring of the production process;
· This machine is a full servo motor system control model, and the parameters that need to be adjusted can be modified on the touch screen;
· Adopting advanced electric control system, with stepless speed adjustment and comprehensive interlocking functions; all operational parameters are displayed centrally;
· Temperature record and curve graph automatically record and print;
· It has full-line linkage function, enabling linkage control of front and rear equipment.
Cleaning process: Utilizes ultrasonic cleaning and sterilization to remove impurities, dust and microorganisms in the bottles to ensure the cleanliness of cartridge bottles and meet the production requirements of pharmaceutical filling;
Sterilization oven: The sterilization oven is suitable for drying and sterilizing ampoules, vials, cartridge bottles, as well as other medicinal glass bottles; the heat source of the tunnel-type hot air circulation oven is evenly distributed, and the pyrogen removal effect is good;
Bottle conveying: The automatic conveying system sends the cartridge bottles into the filling station in an orderly manner;
Precise filling: Liquid or semi-liquid products are injected into bottles through high-precision pump or gravity filling system;
Stoppering and sealing: The servo motor-driven stoppering process ensures high stability and success rates;
Quality Inspection: Equipped with visual inspection system to monitor filling volume and sealing quality in real time, automatically rejecting unqualified products;
Packing and discharge: After finishing filling and sealing, the products automatically enter the packing line for final preparation.

The cartridge bottle filling line, with its high efficiency, precision, and flexibility, has become an indispensable equipment in modern production, empowering enterprises to enhance product quality and boost market competitiveness.

Wide applicable specifications, large capacity and high filling accuracy

Applicable Specifications	1ml-5ml
Production Capacity	~12000 bottles/hour
Number of Stoppering Heads	10
Number of Filling Heads	20 (divided into two fillings)
Filling Accuracy	±5%(according to drug characteristics and filling volume)
Pass Rate of Plugging	≥99%
Capping Qualification Rate	≥99%
Power Requirement	220V/380V, 50/60Hz
Air Source Requirement	0.6-0.8 MPa

Pharmaceutical industry: Used for filling vaccines, insulin, antibiotics, interferon, anesthesia sedatives and other drugs.

Medical industry: Finished products are used in ophthalmology, stomatology, otology, orthopedics, gynecology and so on.

Cosmetic industry: For the filling of serum, hyaluronic acid/collagen, hydrodermic injections/microneedle solutions and other products.
Automatic bottle loading system: to realize automatic bottle feeding, reduce manual operation.

Labeling system: to provide automatic labeling to improve packaging efficiency.

Regulatory code system: to print QR code on the packaging of different levels of products, with identification and correlation between the QR code, which facilitates the traceability and management of the quality of product batches.

Audit tracing system: contains product batch records, operation logs, electronic signature traceability, etc. It meets the requirements of FDA 21CFR part 11 for software systems.

Configurable systems:
· Online cleaning and sterilization CIP/SIP system;
· Online sterilization function for the cooling section of tunnel-type hot air circulation oven;
· Vacuum filling system for filling high viscosity products;
· Fully enclosed sterile isolator system can be equipped according to whether the customer’s products are toxic or active.

Why MARYA

Trusted Worldwide

20 +

Years rich Industry Experience

3 +

Production Bases

60 +

Successful Projects in 60 Countries

300 +

Loyal Clientele

Company Honors and Certificates

CE Bottle unscrambler and labeling machine

Some of Our Customers

Well - known visiting Clients

Invited to the Embassy of the United Republic of Tanzania in Guangzhou to discuss projects

NBA (Zimbabwe National Biotechnology Authority) conducts FAT at MARYA’s Factory

NOVO NORDISK client Visit

Argentine client visits for FAT in MARYA

Successful Cases

Argentina Vial and Ampoule line

Malaysia Prefilled Syringe Filling line

Zimbabwe Vial Filling Line

INTERESTED IN MARYA?

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Services

Full-process Consulting Services

Whether you are preparing to build a new pharmaceutical factory, build a cleanroom that complies with local GMP regulations, or purchase pharmaceutical equipment to develop a new production line, whether it is a separate cleanroom or pharmaceutical machine project, or a one-stop solution, Marya's professional teams in the fields of pharmaceutical technical process, process equipment, decoration engineering, HVAC engineering, pipeline engineering, utility equipment, intelligent automatic control systems, project cost and other fields can provide you with full-process technical consulting services, and solve your needs one-on-one.

2D/3D Design Modeling Services

Marya project design team is composed of professional CAD and BIM engineers with more than 20 years of comprehensive industry experience and can provide you with comprehensive design services, including but not limited to process layout drawings, technical process charts, 3D models and animations, air conditioning system scheme design, construction drawing design, plant/pharmaceutical machine layout drawings, etc.

Machine Customization Services

Based on the individual needs of clients in different countries, Marya helps you clarify specific needs, match appropriate models, and customize one stop filling solutions for sterile small-volume preparations, large-volume injections, oral liquids/syrups, solid preparations, etc.

Validation Services (FAT/SAT)

Marya will appoint an engineer with rich project management experience as the person in charge, who will be fully responsible for project management and liaison work. After the equipment is manufactured, our engineers and the buyer's representatives will participate in the FAT test. After the equipment arrives at the buyer's site, it will be installed and debugged. After the equipment reaches optimal operation, the buyer will conduct SAT testing and inspection.

Customer FAQ

Are you manufacturer or trader? Where are your factory located?

We are manufacturer. Our factory is located in Changsha and Suzhou.

What certificate do you have?

We have CE, ISO, ROHS, SGS etc.

What documents will you provide?

Usually we will provide DQ, IQ, PQ, OQ, FAT, SAT, operation manual, maintenance instruction,layout drawing.etc.

What is the production lead time?

Standard 25-60 days after deposit received and technical data confirmed, we can make special arrangement for better shipment if needed;
Standard 60-150 days after deposit received and technical data confirmed based on different machines, we can make special arrangement for better shipment if needed.

How long is your warranty? Can we extend?

12 months after installation and commissioning or 18 moths from the day that the equipment arrived on site. Prevail in the first arrival date.
Warranty can be extended with extra charge.

Have you done similar projects overseas?

Marya’s business map covers more than 60 countries and regions around the world, such as the United States, Russia, Bulgaria, Britain, Portugal, Poland, Switzerland, ltaly, New Zealand, Malta, Moldova, Malaysia, Uzbekistan, lran, Egypt, Saudi Arabia, UAE, Ecuador, Dominica, Panama, Uruguay, Argentina, Tanzania, Zimbabwe, Ethiopia, Indonesia, Bangladesh, and others, and we gained good reputation.

Key words:

Cartridge Filling Line

Cartridge Filling Capping Line

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