Welcome to Shanghai Marya Pharmaceutical Engineering & Project Co., Ltd.

Home
About Marya
Products
Cases
Solutions
Services
News
Contact Us

Language
- 中文简体
- 中文繁體
- English
- 日本語
- 한국인
- Français
- Deutsch

Home page

Products

Pharmaceutical Multi-effect Distilled Water Machine

The Multi-effect Water Distiller is a specialized equipment for the production of high purity distilled water. Providing a flexible one-stop solution for generating pharmaceutical-grade water for injection (WFI) based on distillation (i.e., thermal process). It is mainly used in application scenarios such as liquid preparation and biological fermentation.

Working Principle
Core Features
Technical Parameters
Application Industry

The multi-effect distilled water machine utilizes the principle of multi-stage evaporation and condensation. The purified water that has been fully preheated passes through the first-effect evaporator heated by industrial steam to generate secondary steam. This secondary steam serves as the heating steam for the next effect. The concentrated water from the previous effect is used as the raw water for the subsequent effect and is heated and evaporated again. This process is repeated successively. Finally, the generated steam is condensed by the cooling water, and the non-condensable gases and impurities are removed. The steam condenses in the condenser, thus obtaining high-purity distilled water.
1.Three - stage separation with an external spiral structure, including falling - film flash evaporation separation, 180° return force separation, and external spiral centrifugal separation.
2.Double tube - sheet design to prevent cross - contamination. The inner tube - sheet is connected to the outer tube - sheet by expansion.
3.The parts in contact with raw water, cooling water, pure steam, and distilled water are made of stainless steel 316L, and the seals are made of PTFE.
4.A non - condensable gas discharge device is installed.
5.The first - effect evaporator can produce pure steam (optional).
6.We can provide Validation documents include DQ, IQ, OQ.

Design Pressure（MPa)	0.6
Working Pressure(MPa)	0.3~0.5
WFI output（L/h）	100L/H~5000L/H
WFI temperature(℃)	92~99
PH Value	5.0-7.0
Conductivity (at 20 °C)	≤1.0μs/cm
Total Organic Carbon (TOC)	≤250ppb（20℃）
Bacterial Endotoxin	≤0.125 EU/ml
Microbial Limit	Escherichia coli, Salmonella, and Pseudomonas aeruginosa shall not be detected
	The total number of bacteria, molds, and yeasts shall not exceed 2 per 100 ml
	The total number of bacteria, molds, and yeasts shall not exceed 10 per 100 ml
Other indicators of Water for Injection comply with	Chinese Pharmacopoeia (2020 Edition)
	United States Pharmacopeia (USP38)
	European Pharmacopoeia (EP6.8)

Why MARYA

Trusted Worldwide

20 +

Years rich Industry Experience

3 +

Production Bases

60 +

Successful Projects in 60 Countries

300 +

Loyal Clientele

Company Honors and Certificates

CE Bottle unscrambler and labeling machine

Some of Our Customers

Well - known visiting Clients

Invited to the Embassy of the United Republic of Tanzania in Guangzhou to discuss projects

NBA (Zimbabwe National Biotechnology Authority) conducts FAT at MARYA’s Factory

NOVO NORDISK client Visit

Argentine client visits for FAT in MARYA

Successful Cases

Argentina Vial and Ampoule line

Malaysia Prefilled Syringe Filling line

Zimbabwe Vial Filling Line

INTERESTED IN MARYA?

Get In Touch With Us.

We Will Be Happy To Discuss Our Solutions And Services With You.

Contact Now

Services

Full-process Consulting Services

Whether you are preparing to build a new pharmaceutical factory, build a cleanroom that complies with local GMP regulations, or purchase pharmaceutical equipment to develop a new production line, whether it is a separate cleanroom or pharmaceutical machine project, or a one-stop solution, Marya's professional teams in the fields of pharmaceutical technical process, process equipment, decoration engineering, HVAC engineering, pipeline engineering, utility equipment, intelligent automatic control systems, project cost and other fields can provide you with full-process technical consulting services, and solve your needs one-on-one.

2D/3D Design Modeling Services

Marya project design team is composed of professional CAD and BIM engineers with more than 20 years of comprehensive industry experience and can provide you with comprehensive design services, including but not limited to process layout drawings, technical process charts, 3D models and animations, air conditioning system scheme design, construction drawing design, plant/pharmaceutical machine layout drawings, etc.

Machine Customization Services

Based on the individual needs of clients in different countries, Marya helps you clarify specific needs, match appropriate models, and customize one stop filling solutions for sterile small-volume preparations, large-volume injections, oral liquids/syrups, solid preparations, etc.

Validation Services (FAT/SAT)

Marya will appoint an engineer with rich project management experience as the person in charge, who will be fully responsible for project management and liaison work. After the equipment is manufactured, our engineers and the buyer's representatives will participate in the FAT test. After the equipment arrives at the buyer's site, it will be installed and debugged. After the equipment reaches optimal operation, the buyer will conduct SAT testing and inspection.

Customer FAQ

Are you manufacturer or trader? Where are your factory located?

We are manufacturer. Our factory is located in Changsha and Suzhou.

What certificate do you have?

We have CE, ISO, ROHS, SGS etc.

What documents will you provide?

Usually we will provide DQ, IQ, PQ, OQ, FAT, SAT, operation manual, maintenance instruction,layout drawing.etc.

What is the production lead time?

Standard 25-60 days after deposit received and technical data confirmed, we can make special arrangement for better shipment if needed;
Standard 60-150 days after deposit received and technical data confirmed based on different machines, we can make special arrangement for better shipment if needed.

How long is your warranty? Can we extend?

12 months after installation and commissioning or 18 moths from the day that the equipment arrived on site. Prevail in the first arrival date.
Warranty can be extended with extra charge.

Have you done similar projects overseas?

Marya’s business map covers more than 60 countries and regions around the world, such as the United States, Russia, Bulgaria, Britain, Portugal, Poland, Switzerland, ltaly, New Zealand, Malta, Moldova, Malaysia, Uzbekistan, lran, Egypt, Saudi Arabia, UAE, Ecuador, Dominica, Panama, Uruguay, Argentina, Tanzania, Zimbabwe, Ethiopia, Indonesia, Bangladesh, and others, and we gained good reputation.

Key words:

None

:Next

Pure Steam Generator

Contact MARYA Engineers to Claim Your Free GMP compliant Sterile Water Treatment Solution