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Products

RTU Vial Syringe Cartridge Filling Machine

RTU (Ready-To-Use) Vial Syringe Cartridge Filling Machine is a multi-container compatible, fully enclosed and sterile intelligent integrated system, which can automatically complete the whole process of unpacking, filling and stoppering. It is specially designed for high-end pharmaceuticals such as vaccines and biological preparations, ensuring aseptic and compliant production. Featuring a modular flexible design, it supports quick changeover and complies with cGMP/FDA requirements, significantly enhancing production efficiency and drug safety.

Core Advantages
Core Technology
Technical Parameters
Application Scenarios
Optional Systems

Multi-container compatibility:
· Fast changeover: Supports multiple specification containers (vials, pre-filled syringes, cartridges), changeover time for specification parts ≤ 60 minutes.
· Adaptive clamping: High-precision servo-controlled clamps prevent scratches and deformation.
Aseptic operation: The whole filling and stoppering process is aseptic, preventing microbial contamination.
Ultra-precision filling: Ceramic pumps, peristaltic pumps, mass flow meters achieve ±1% accuracy. And it’s adaptable to diverse drug formulations and packaging materials.
Easy integration: Modular design interfaces seamlessly with front and rear equipment, allowing future upgrades.
Easy maintenance: Quick-disassembly structure reduces cleaning time and maintenance costs.
Flexible production mode: Supports single batch and continuous production, etc.
High stability: Ensures consistent quality during long operation periods.
Regulatory compliance: Meets GMP, FDA 21CFR part11 and other regulations.
Intelligent features:
· Touch screen adjustment of filling volume and plugging depth with servo motor independent pump control.
· Full traceability: MES system records data and supports electronic batch records.
· Safety: detection of plug lack, overload protection, abnormal condition alarm ensure 100% stoppering.
Sterility guarantee: ISO Class 5 isolator + VHP online sterilization (≥6-log decontamination)
Pollution-free filling: Pre-filled syringe filling heads with suspension positioning technology, avoiding liquid splashing and reducing the risk of cross-contamination by 90%.
High-precision sealing:
· Syringes: particle-free rubber stopper press-fit, passing USP<1207> sealing test
· Vials/Cartridges: Electromagnetic induction capping, with ±1% torque control accuracy, ensuring leak-proof aluminum seal
Antioxidant protection: Equipped with nitrogen filling system to meet the antioxidant process requirements during drug filling and storage;
Seal detection: High sensitivity negative pressure detection; leakage resolution up to 0.05ccm; real-time rejection of micro-leakage products.

Items	Parameters
Applicable Containers	Vial(2R~30R), pre-filled syringe(1ml~10ml), cartridge (1.5-3ml)
Filling Accuracy	±0.2% (syringe) /±0.5% (vial/cartridge)
Production Speed	Vial: 200 bottles/min; Pre-filled syringe/Cartridge: 350 pcs/min (maximum speed)
Cleanliness Class	ISO Level 5 (Level A environment)
Power Requirement	380V±10%, 50/60Hz
Compressed Air Requirement	0.7MPa, no oil and water (dew point ≤-40℃)

Biologics: ready-to-use dispensing of monoclonal antibodies, dual antibodies, ADC drugs, cell therapy solutions.
Vaccine field: pre-filled syringe encapsulation of mRNA vaccines, recombinant protein vaccines.
High-end medical aesthetics: aseptic cartridge filling for hyaluronic acid, Poly-L-lactic acid treatments(“Youth Boosters”), collagen.
Chronic disease medication: automated production of pen cartridges for insulin, GLP-1 receptor agonists.
Emergency medicines: ready-to-use packaging of epinephrine pre-filled syringes and anticoagulants.
· Isolator + RTP interface: optional C-RABS and O-RABS protection to realize aseptic operation in Class A environment.
· Online sterilization plunger pump can be configured to realize CIP/SIP function of filling system.
· Lyophilizer linkage module: Directly interface with lyophilization process after filling of vials, reducing the intermediate exposure link.
· Automatic siliconization system: silicone oil spraying on the inner wall of pre-filled syringe; uniformity CV≤3%, reducing injection thrust.
· Particle monitoring system: Online monitoring of the number of particles ≥ 0.5μm in the filling area; real-time data warning.
· AGV logistics integration: Seamless interface with intelligent warehouse system to realize unmanned material turnover.
· Adopt PMS online monitoring system, achieving real-time monitoring of sterile production environment and data traceability.

Why MARYA

Trusted Worldwide

20 +

Years rich Industry Experience

3 +

Production Bases

60 +

Successful Projects in 60 Countries

300 +

Loyal Clientele

Company Honors and Certificates

CE Bottle unscrambler and labeling machine

Some of Our Customers

Well - known visiting Clients

Invited to the Embassy of the United Republic of Tanzania in Guangzhou to discuss projects

NBA (Zimbabwe National Biotechnology Authority) conducts FAT at MARYA’s Factory

NOVO NORDISK client Visit

Argentine client visits for FAT in MARYA

Successful Cases

Argentina Vial and Ampoule line

Malaysia Prefilled Syringe Filling line

Zimbabwe Vial Filling Line

INTERESTED IN MARYA?

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Services

Full-process Consulting Services

Whether you are preparing to build a new pharmaceutical factory, build a cleanroom that complies with local GMP regulations, or purchase pharmaceutical equipment to develop a new production line, whether it is a separate cleanroom or pharmaceutical machine project, or a one-stop solution, Marya's professional teams in the fields of pharmaceutical technical process, process equipment, decoration engineering, HVAC engineering, pipeline engineering, utility equipment, intelligent automatic control systems, project cost and other fields can provide you with full-process technical consulting services, and solve your needs one-on-one.

2D/3D Design Modeling Services

Marya project design team is composed of professional CAD and BIM engineers with more than 20 years of comprehensive industry experience and can provide you with comprehensive design services, including but not limited to process layout drawings, technical process charts, 3D models and animations, air conditioning system scheme design, construction drawing design, plant/pharmaceutical machine layout drawings, etc.

Machine Customization Services

Based on the individual needs of clients in different countries, Marya helps you clarify specific needs, match appropriate models, and customize one stop filling solutions for sterile small-volume preparations, large-volume injections, oral liquids/syrups, solid preparations, etc.

Validation Services (FAT/SAT)

Marya will appoint an engineer with rich project management experience as the person in charge, who will be fully responsible for project management and liaison work. After the equipment is manufactured, our engineers and the buyer's representatives will participate in the FAT test. After the equipment arrives at the buyer's site, it will be installed and debugged. After the equipment reaches optimal operation, the buyer will conduct SAT testing and inspection.

Customer FAQ

Are you manufacturer or trader? Where are your factory located?

We are manufacturer. Our factory is located in Changsha and Suzhou.

What certificate do you have?

We have CE, ISO, ROHS, SGS etc.

What documents will you provide?

Usually we will provide DQ, IQ, PQ, OQ, FAT, SAT, operation manual, maintenance instruction,layout drawing.etc.

What is the production lead time?

Standard 25-60 days after deposit received and technical data confirmed, we can make special arrangement for better shipment if needed;
Standard 60-150 days after deposit received and technical data confirmed based on different machines, we can make special arrangement for better shipment if needed.

How long is your warranty? Can we extend?

12 months after installation and commissioning or 18 moths from the day that the equipment arrived on site. Prevail in the first arrival date.
Warranty can be extended with extra charge.

Have you done similar projects overseas?

Marya’s business map covers more than 60 countries and regions around the world, such as the United States, Russia, Bulgaria, Britain, Portugal, Poland, Switzerland, ltaly, New Zealand, Malta, Moldova, Malaysia, Uzbekistan, lran, Egypt, Saudi Arabia, UAE, Ecuador, Dominica, Panama, Uruguay, Argentina, Tanzania, Zimbabwe, Ethiopia, Indonesia, Bangladesh, and others, and we gained good reputation.

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