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Products

Vial Powder Filling Sealing Production Line

The vial powder filling sealing production line consists of ultrasonic bottle washing machine, dryer and sterilizer, injectable powder filling machine, vial powder stoppering and capping machine. It can complete the complex functions of water spraying, ultrasonic cleaning, flushing of inner and outer wall of bottle, preheating, drying and sterilization, de-pyrogen, cooling, bottle unscrambling, filling, stoppering unscrambling, stoppering pressing, cap unscrambling, capping, etc., realizing automatic production of the whole process .

Core Advantages
Core Technology
Technical Parameters
Application Scenarios
Optional Systems

High filling accuracy: Up to ±3% filling deviation, fully meets GMP standards
Fully automated operation: Minimizes manual intervention to reduce contamination risks
Sterility assurance: Isolator system ensures clean production environment
Production flexibility: Quick changeover to meet the needs of multiple specifications
Stability and efficiency: Servo-driven system ensures continuous stable operation
Feeding system: Multiple sterile material feeding options, in line with GMP requirements
Intelligent control: PLC + touchscreen for fully automated monitoring
Compact design: Space-saving footprint and reasonable layout
Sterilization Oven: Evenly distributed heat in the hot air circulation tunnel oven with good depyrogenation effect;
Powder Filling: High-precision screw is used to realize precise filling of sterile powder, eliminating secondary contamination;
Vial Positioning: Photoelectric sensors and mechanical positioning systems are used to ensure precise vial positioning during filling;
Sealing & Capping: Automatically completes aluminum cap sealing/rubber plug capping post-filling;
Online Inspection: Integrated in-line weighing for 100% quality control.

Specifications	5ml~50mlvial bottles (according to per customer’s requirement)
Production Capacity	6000-30000BPH
Filling Heads	1-4, to be selected according to the output
Filling Accuracy	≤±3%(according to drug characteristics and filling volume)
Capping Qualified Rate	≥99.9%
FillingSpeed	100 bottles/min (adjustable according to demand)
Power Requirement	380V，50-60Hz
Air Source Requirement	0.6-0.8 MPAclean compressed air
Clean Level	Meet GMP Level A requirements

Pharmaceutical industry: For filling antibiotics, freeze-dried powder injection, vaccines and other powdered drugs.

Biological products: For aseptic filling of high-end biological products, such as biological preparations and cell cultures.

Cosmetic industry: For powder filling of high-end skin care products, such as mask powder, essence powder, etc.

Food industry: Suitable for powder filling of functional foods and nutritional supplements.
▸ Sterility Assurance System
Optional o-RABS/isolation protection system or aseptic isolator system;
Optional sterilization temperature real-time display & printing system;
Optional online sterilization function for the cooling section of the hot air tunnel oven;
Optional CIP/SIP system: to ensure compliance with GMP requirements, guaranteeing residue-free cleaning.

▸ Intelligent Inspection System
Online weighing system: Real-time monitoring of the weight of each bottle of powder to ensure filling accuracy.
Online monitoring system: It can monitor the key factors affecting product quality (such as dust particles, planktonic bacteria, wind speed, wind pressure, etc.);

▸ Automated Control System
Servo automatic feeding: Automatic feeding and filling of powder and less manual operation.
Intelligent error-proofing: no bottle no filling, no bottle no stoppering, no bottle no capping and auto-stop function for bottle squeeze or vial missing;
Aluminum dust extraction: It can remove aluminum particles generated during capping, reducing the risk of environmental pollution.

▸ Quality Tracing System
Supervisory code system: Equipped with QR codes or bar codes for complete product traceability.
Standard real-time display of sterilization temperature & printing system.

▸ Customization Services
Modular design, flexible configuration.
Supports special process customization.
Provides validation services support.

Why MARYA

Trusted Worldwide

20 +

Years rich Industry Experience

3 +

Production Bases

60 +

Successful Projects in 60 Countries

300 +

Loyal Clientele

Company Honors and Certificates

CE Bottle unscrambler and labeling machine

Some of Our Customers

Well - known visiting Clients

Invited to the Embassy of the United Republic of Tanzania in Guangzhou to discuss projects

NBA (Zimbabwe National Biotechnology Authority) conducts FAT at MARYA’s Factory

NOVO NORDISK client Visit

Argentine client visits for FAT in MARYA

Successful Cases

Argentina Vial and Ampoule line

Malaysia Prefilled Syringe Filling line

Zimbabwe Vial Filling Line

INTERESTED IN MARYA?

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Services

Full-process Consulting Services

Whether you are preparing to build a new pharmaceutical factory, build a cleanroom that complies with local GMP regulations, or purchase pharmaceutical equipment to develop a new production line, whether it is a separate cleanroom or pharmaceutical machine project, or a one-stop solution, Marya's professional teams in the fields of pharmaceutical technical process, process equipment, decoration engineering, HVAC engineering, pipeline engineering, utility equipment, intelligent automatic control systems, project cost and other fields can provide you with full-process technical consulting services, and solve your needs one-on-one.

2D/3D Design Modeling Services

Marya project design team is composed of professional CAD and BIM engineers with more than 20 years of comprehensive industry experience and can provide you with comprehensive design services, including but not limited to process layout drawings, technical process charts, 3D models and animations, air conditioning system scheme design, construction drawing design, plant/pharmaceutical machine layout drawings, etc.

Machine Customization Services

Based on the individual needs of clients in different countries, Marya helps you clarify specific needs, match appropriate models, and customize one stop filling solutions for sterile small-volume preparations, large-volume injections, oral liquids/syrups, solid preparations, etc.

Validation Services (FAT/SAT)

Marya will appoint an engineer with rich project management experience as the person in charge, who will be fully responsible for project management and liaison work. After the equipment is manufactured, our engineers and the buyer's representatives will participate in the FAT test. After the equipment arrives at the buyer's site, it will be installed and debugged. After the equipment reaches optimal operation, the buyer will conduct SAT testing and inspection.

Customer FAQ

Are you manufacturer or trader? Where are your factory located?

We are manufacturer. Our factory is located in Changsha and Suzhou.

What certificate do you have?

We have CE, ISO, ROHS, SGS etc.

What documents will you provide?

Usually we will provide DQ, IQ, PQ, OQ, FAT, SAT, operation manual, maintenance instruction,layout drawing.etc.

What is the production lead time?

Standard 25-60 days after deposit received and technical data confirmed, we can make special arrangement for better shipment if needed;
Standard 60-150 days after deposit received and technical data confirmed based on different machines, we can make special arrangement for better shipment if needed.

How long is your warranty? Can we extend?

12 months after installation and commissioning or 18 moths from the day that the equipment arrived on site. Prevail in the first arrival date.
Warranty can be extended with extra charge.

Have you done similar projects overseas?

Marya’s business map covers more than 60 countries and regions around the world, such as the United States, Russia, Bulgaria, Britain, Portugal, Poland, Switzerland, ltaly, New Zealand, Malta, Moldova, Malaysia, Uzbekistan, lran, Egypt, Saudi Arabia, UAE, Ecuador, Dominica, Panama, Uruguay, Argentina, Tanzania, Zimbabwe, Ethiopia, Indonesia, Bangladesh, and others, and we gained good reputation.

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