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Ampoule Filling Sealing Line

The Ampoule Filling and Sealing line is suitable for the production of small volume injections, vaccines, biological preparations, etc. It is an efficient and precise automated equipment designed for pharmaceutical and biotechnology industries for filling and sealing of ampoules. The equipment integrates advanced filling technology and sealing process, which meets international standards such as GMP and FDA, and ensures the sterility and safety of pharmaceuticals in the production process.

Core Advantages
Core Technology
Technical Parameters
Application Scenarios
Optional Systems

▸ Performance Advantages
High-precision filling: driven by servo motor, the filling precision can reach up to ±0.5%, ensuring consistent liquid volume in each ampoule.
Aseptic operation: the equipment is equipped with aseptic isolation system, which complies with GMP standards and ensures that the drugs are not contaminated during the production process.
Efficient production: high degree of automation; production speed up to 400 pcs per minute, improving production efficiency.
Excellent flexibility: It can be adapted to ampoules of different specifications, which is convenient for switching, reducing downtime.
Stability and reliability: Adopting high quality materials and precision processing technology, the equipment runs stably with low failure rate.
Cleaning process: Equipped with ultrasonic cleaning system to ensure the cleanliness of ampoule before filling.
Drying and sterilization: Efficient and precise temperature control, sterilization and depyrogenation, guaranteeing the sterility of package materials.
Filling process: Peristaltic pumps or plunger pumps are used for precise filling to ensure the volume of drug solution is accurate.
Sealing process: Adopting flame drawing sealing technology to ensure the ampoule is well sealed without leakage. The success rate is over 99.8%.
Filling Accuracy ±5%
Production Speed 400 pcs/min (adjustable)
Specification 1ml, 2ml, 5ml, 10ml, 20ml, etc.
Power Requirement 220V/380V, 50Hz/60Hz
Air Source Requirement 0.6-0.8 MPa
Ampoules are widely used in pharmaceutical, medical and cosmetic fields. Known for their excellent hermeticity and low production costs, they serve as one of the most common containers for drug encapsulation.

Pharmaceutical field: filling and sealing for small volume injections (aqueous/oily injections), vaccine, serum, antibiotics and other sterile preparations.
Biotechnology: cell culture fluid, gene therapy drugs, mRNA vaccines and other high-end biological products production.
Scientific research institutions: small batch sample preparation in laboratories, pilot-scale process validation.
Medical Aesthetics: encapsulation of hyaluronic acid, collagen and other high-end medical beauty products.
Aseptic isolation system: to ensure an aseptic production environment compliant with GMP requirements.
Visual inspection system: to monitor product quality in real-time with automatic rejection of substandard products.
Automatic feeding system: to realize automatic feeding of ampoules, reducing manual operation.
Data tracing system: to record the key data in the production process, facilitating quality tracing and management.
Laser coding system: to print the production batch number, validity period and other information on ampoules, which is convenient for product traceability.

Years rich Industry Experience

Production Bases

Successful Projects in 60 Countries

300 +

Loyal Clientele

CE Bottle unscrambler and labeling machine

Invited to the Embassy of the United Republic of Tanzania in Guangzhou to discuss projects

Tanzanian Vice President Visits Marya Pharmaceutical EPC Project

NBA (Zimbabwe National Biotechnology Authority) conducts FAT at MARYA’s Factory

NOVO NORDISK client Visit

Clients visit the factory's liquid preparation system

Argentine client visits for FAT in MARYA

INTERESTED IN MARYA?

Get In Touch With Us.

We Will Be Happy To Discuss Our Solutions And Services With You.

Whether you are preparing to build a new pharmaceutical factory, build a cleanroom that complies with local GMP regulations, or purchase pharmaceutical equipment to develop a new production line, whether it is a separate cleanroom or pharmaceutical machine project, or a one-stop solution, Marya's professional teams in the fields of pharmaceutical technical process, process equipment, decoration engineering, HVAC engineering, pipeline engineering, utility equipment, intelligent automatic control systems, project cost and other fields can provide you with full-process technical consulting services, and solve your needs one-on-one.

Marya project design team is composed of professional CAD and BIM engineers with more than 20 years of comprehensive industry experience and can provide you with comprehensive design services, including but not limited to process layout drawings, technical process charts, 3D models and animations, air conditioning system scheme design, construction drawing design, plant/pharmaceutical machine layout drawings, etc.

Based on the individual needs of clients in different countries, Marya helps you clarify specific needs, match appropriate models, and customize one stop filling solutions for sterile small-volume preparations, large-volume injections, oral liquids/syrups, solid preparations, etc.

Marya will appoint an engineer with rich project management experience as the person in charge, who will be fully responsible for project management and liaison work. After the equipment is manufactured, our engineers and the buyer's representatives will participate in the FAT test. After the equipment arrives at the buyer's site, it will be installed and debugged. After the equipment reaches optimal operation, the buyer will conduct SAT testing and inspection.

Are you manufacturer or trader? Where are your factory located?

We are manufacturer. Our factory is located in Changsha and Suzhou.

What certificate do you have?

We have CE, ISO, ROHS, SGS etc.

What documents will you provide?

Usually we will provide DQ, IQ, PQ, OQ, FAT, SAT, operation manual, maintenance instruction,layout drawing.etc.

What is the production lead time?

Standard 25-60 days after deposit received and technical data confirmed, we can make special arrangement for better shipment if needed;
Standard 60-150 days after deposit received and technical data confirmed based on different machines, we can make special arrangement for better shipment if needed.

How long is your warranty? Can we extend?

12 months after installation and commissioning or 18 moths from the day that the equipment arrived on site. Prevail in the first arrival date.
Warranty can be extended with extra charge.

Have you done similar projects overseas?

Marya’s business map covers more than 60 countries and regions around the world, such as the United States, Russia, Bulgaria, Britain, Portugal, Poland, Switzerland, ltaly, New Zealand, Malta, Moldova, Malaysia, Uzbekistan, lran, Egypt, Saudi Arabia, UAE, Ecuador, Dominica, Panama, Uruguay, Argentina, Tanzania, Zimbabwe, Ethiopia, Indonesia, Bangladesh, and others, and we gained good reputation.

Key words:

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NO211, North Fute Road, Pudong area, Shanghai, China, 200131

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Filling Accuracy	±5%
Production Speed	400 pcs/min (adjustable)
Specification	1ml, 2ml, 5ml, 10ml, 20ml, etc.
Power Requirement	220V/380V, 50Hz/60Hz
Air Source Requirement	0.6-0.8 MPa