How to ensure the sealing performance of vials

2024-04-02

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Marya

Vials are drug sealed containers which are widely used in the pharmaceutical field, generally composed of a bottle, a rubber stopper, and a aluminum cap. There are many factors that affect the sealing performance of vials, for example, whether there is a mechanical and pressure difference between each capping head of the capping machine in the production line, whether the material of the aluminum cap meets the hardness index required, whether the rubber stopper is too soft or hard, whether the angle and thickness of the bottle mouth are reasonably designed, and so on.

Vials are drug sealed containers which are widely used in the pharmaceutical field, generally composed of a bottle, a rubber stopper, and a aluminum cap. There are many factors that affect the sealing performance of vials, for example, whether there is a mechanical and pressure difference between each capping head of the capping machine in the production line, whether the material of the aluminum cap meets the hardness index required, whether the rubber stopper is too soft or hard, whether the angle and thickness of the bottle mouth are reasonably designed, and so on.

So how to ensure the sealing performance of the vial to ensure the quality of the drug?

Marya has been deeply involved in sterile filling in the pharmaceutical industry for many years, and we have a complete set of solutions for this. In this article we will discuss that from the aspect of capping pressure of vials.

For vial capping

1、The rubber stopper of vial is an important component. Its material characteristics will affect the pressure and deformation applied in the capping process. The deformation of rubber stopper with different materials will be different after being stressed. Some materials may be easily deformed, while other materials need higher pressure to be appropriately deformed.

2、The aluminum cap is also one of the factors that affect the tightness of the vial. Under the same initial pressure, if the inner depth of the aluminum cap is too high, it will lead to excessive extruded aluminum materials, resulting in irregular edge or wrinkles. If the aluminum is too hard, it will increase the load of capping motor, irregular edge and wrinkles; and too soft aluminum may cause cap broken.

3、The shape and size of the bottle mouth have an important effect on the capping. Proper shape and size can ensure close contact between bottle cap and mouth, so as to achieve good sealing effect.

4、Marya has launched a variety of high-end products in response to the growing demand for high-performance vial filling equipment in the pharmaceutical market, including commercial vial filling lines and single-station vial filling capping machines applicable for laboratory research and development.

5、A flexible capping process is adopted. By the constant driving force through an air spring and the active rotation of bottles, the capping knife folds the aluminum cap edge, makes the edgefold consistent with the capping angle and presses the cap. It can avoid the problems of loose or over-tight capping, poor capping effect, wear, wrinkles and the like, and effectively improve the rate of finished products. The capping pressure can be monitored in real time during capping process, and the flexible capping mode can be used to ensure the tightness of products in life cycle on the basis of reducing aluminum chips.

Technology Application of Cleanroom Isolator

Marya's Vial Filling Line-Flexibility and High-Performance